To surrogate or not surrogate: an ancient dilemma without a happy ending

Giandomenico Roviello


Haslam et al. performed an analysis of surrogate validation studies (1), in order to evaluate the strength of correlation between overall survival (OS) and surrogate markers. The analysis included 78 studies that according the inclusion criteria were meta-analyses of randomised controlled trials that investigated the validation as surrogate endpoint for survival of progression free survival or tumour response rate.